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By "stages of dementia" we mean, for example: Early Stage Dementia (Mild Cognitive Impairment), which may be characterized by language difficulties (vocabulary recall, shrinking vocabulary, fluency, etc.)
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Ex vivo rectal tumour samples more accurately reflect the dynamic tumour microenvironment, the complex architecture of the tumour, and the inherent genetic diversity between patients and therefore, this data supports metformin as a metabolic modulator in rectal tumours