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The animal literature is unusually consistent, though: nearly every published in vivo study used 5 mg/kg per injection, given three times on alternate days (days 1, 3, and 5, or days 14, 16, and 18 in the pulmonary fibrosis model), with effects tracked over the following three to four weeks
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Immunological safety profiling of MOTS-c indicates a very low incidence of hypersensitivity reactions or systemic allergic responses, though rare instances of mild cutaneous rashes, localized urticaria, or low-titer antibody generation have been documented following chronic, high-dose exposure in complex experimental models, emphasizing the critical importance of utilizing ultra-pure, HPLC-verified material and adhering strictly to established dosing guidelines to minimize any risk of immunogenic sensitization or adverse inflammatory cascades
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